Chair of Computational Mathematics Seminar: Measuring the Speed of Biochemical Reactions

Chair Of Computational Mathematics

Chair Of Computational Mathematics

03/02/2017
12:00 – 14:00
Central Meeting Room at DeustoTech. DeustoTech ­ University of Deusto Av. de las Universidades, 24 48007 Bilbao ­ Basque Country ­ Spain
 

COMPUTATIONAL MATHEMATICS SEMINAR


Measuring the Speed of Biochemical Reactions

Ryan Evans
Applied and Computational Mathematics Division,
National Institute of Standards and Technology (U.S.A.)
Abstract
Many biochemical reactions involve a stream of chemical reactants flowing through a fluid-filled volume, over a surface to which receptors are confined.
Such surface-volume reactions occur during blood clotting, drug-protein interactions, and DNA-damage repair.
Scientists measure reaction rate constants associated with these reactions using optical biosensors: an instrument in which reactants are convected through a flow-cell, over a surface to which other reactants are immobilized.
Scientists currently study biosensor experiments which involve multiple interacting components on the sensor surface. We discuss a partial differential equation model for multiple-component reactions in optical biosensors. Thanks to high Peclet number flow, this model reduces to a set of nonlinear
integrodifferential equations for the reacting species concentrations, which in turn reduces to a set of ordinary differential equations which can be used to measure rate constants using biosensor data. We conclude by discussing
recent developments on a related problem concerning instruments involved in
creating personalized medicine.
 
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